Orly Liba (PhD candidate '18) is the lead author of a study published in Nature Communications. Her advisor, Professor Adam de la Zerda and fellow researchers have devised a way to improve the quality of images obtained through optical coherence tomography (OCT).
The relatively simple, low-cost fix — entailing a pair of lenses, a piece of ground glass and some software tweaks — erases blemishes that have bedeviled images obtained via OCT since its invention in 1991. This improvement, combined with the technology's ability to optically penetrate up to 2 millimeters into tissue, could enable physicians to perform "virtual biopsies," visualizing tissue in three dimensions at microscope-quality resolution without excising any tissue from patients.
Their study describes how the researchers tested the enhancement in two different commercially available OCT devices. They were able to view cell-scale features in intact tissues, including in a mouse's ear, retina and cornea, as well as Meissner's corpuscle, found in the skin of a human fingertip.
"We saw sebaceous glands, hair follicles, blood vessels, lymph vessels and more," Liba said.
Other Stanford co-authors of the study are former postdoctoral scholars Matthew Lew, PhD, and Debasish Sen, PhD; graduate student Elliott SoRelle; research assistant Rebecca Dutta; professor of ophthalmology Darius Moshfeghi, MD; and professor of physics and of molecular and cellular physiology Steven Chu, PhD.
Excerpted from "Scientists turbocharge high-resolution, 3-D imaging," published on Stanford Medicine's News Center, June 20, 2017