Abstract: In this talk I will discuss rapid developments, taking place over the past decade or so, in applying uniaxial pressure to quantum materials using piezo-activated vices. In the first stages of using the new experimental capabilities, the focus was on applying large static uniaxial pressures, up to 3 GPa so far, to generate large changes in the physical properties of unconventional superconductors and magnets. The vice provided the tuning of the properties, which were probed by other techniques such as electrical resistivity or magnetic susceptibility. Only more recently has it become clear that exquisitely precise thermodynamic information can be obtained from simultaneously probing the elastic response of the materials to the applied pressure. I will illustrate the power of these new techniques mainly by discussing their application to the normal and superconducting state properties of a material, Sr2RuO4, that I have been working on for far longer than I care (and possibly am able) to remember!