Cancer. Infertility. Hearing loss. Each of these phrases can bring a ray of darkness into an otherwise happy life. The Stanford Biomedical Optics group, led by Professor Audrey Bowden, aims to develop and deploy novel optical technologies to solve interdisciplinary challenges in the clinical and basic sciences. In short, we use light to image life -- and in so doing, illuminate new paths to better disease diagnosis, management and treatment. In this talk, I will discuss our recent efforts to design, fabricate and/or construct new hardware, software and systems-level biomedical optics tools to attack problems in skin cancer, bladder cancer, hearing loss and infertility. Our efforts span development of new fabrication techniques for 3D tissue-mimicking phantoms, new strategies for creating large mosaics and 3D models of biomedical data, machine-learning classifiers for automated detection of disease, novel system advances for multiplexed optical coherence tomography and low-cost technologies for point-of-care diagnostics.