Optical imaging probes like otoscopes and laryngoscopes are essential tools used by doctors to see deep into the human body. Until now, they have been crucially limited to two-dimensional (2D) views of tissue lesions in vivo that frequently jeopardize their diagnostic usefulness. Depth imaging is critically needed in medical diagnostics because most tissue lesions manifest themselves as abnormal 3D structural changes. In this talk, I will talk our recent effort to develop three-dimensional (3D) plenoptic imaging tool that revolutionizes diagnosis with unprecedented sensitivity and specificity in the images produced. Particularly, I will discuss two plenoptic medical cameras, a plenoptic otoscope and a plenoptic laryngoscope, and their applications for in-vivo imaging.