SCIEN Talk

Retinal topography is affected by pathology such as drusen and tumors, and it may be useful to determine topography with fundus imaging when three-dimensional imaging is not available. In this talk, I will present a novel method of retinal topography scanning using the stripe projection technology of the CLARUSTM 700 (ZEISS, Dublin, CA) wide-field fundus camera. The camera projects stripes onto the retina and records images of the returned light while maintaining a small angle between illumination and imaging. We make use of this structured illumination, analyzing neighboring stripes to determine depth -i.e. the retinal topography – from both relative defocus and stripe displacements. The resulting topography maps are finally compared to three-dimensional data from optical coherence tomography imaging.

Single Photon Avalanche Detectors (SPADs) can detect single photon arrival events and in doing so, record a click that can be used to also determine the photon arrival time on the detector with picosecond temporal resolution. This timing capability is finding many uses such as LIDAR and fluorescence lifetime imaging and provides an opportunity for revisiting fundamental imaging concepts by combining SPAD data with computational image retrieval techniques. The computational techniques can in general resort to inverse retrieval approaches or machine learning, with the choice depending on the specific nature of the data and imaging problem at hand. I will overview some of our work, starting from the first attempts to capture light-in-flight using SPAD cameras and covering the topics of non-line-of-sight imaging, imaging through diffusion, extraction of 3D images from time-of-light data only, fluorescence lifetime imaging and coincidence counting for quantum imaging applications.

Additive manufacturing printing, i.e., 3-D printing, is one of the most important technological innovations in the past few decades. Among the various techniques, two-photon polymerization (TPP) is the most precise 3-D printing process that has been used to create many complex structures for advanced photonic and nanoscale applications, e.g., microrobots, optical memories, metamaterials, photonic crystals, and bio-scaffolds etc. However, to date the technology still remains a laboratory tool due to its high operation cost and limited fabrication rate, i.e., serial laser scanning process. In this seminar, I will present our recent work on the parallelization of the TPP process based on (1) temporal focusing and (2) binary holography, where programmable femtosecond light sheets or tens to hundreds of shaped laser beams are used to substantially improve the rate without sacrificing resolution. In addition, the engineered laser foci can improve the strength and structural integrity of the printed structures. Our experiments demonstrate arbitrarily complex structures can be fabricated at a record-breaking resolution and speed, i.e., lateral/axial resolution: 140 nm/175 nm at 10s mm3/min, which is 3-4 orders of magnitude higher than any existing fabrication methods. Our new methods provide an effective and low-cost solution to scale-up the fabrication of functional micro- and nano-structures (~$1.5/mm3). This means our technology may play a large role in fields such as healthcare, clean energy and water, computing, and telecommunications.

With multiple mechanisms of contrast, high sensitivity, high resolution, and the possibility to create miniature, inexpensive devices, light-based techniques have tremendous potential to positively impact cancer detection and survival. Many organs of the body can be reached in a minimally-invasive fashion with small flexible endoscopes. Some organs, such as the fallopian tubes and ovaries, require extremely miniature (sub-mm) and flexible endoscopes to avoid tissue cutting. Additionally, some modalities, such as side-viewing optical coherence tomography, are naturally suited to miniature endoscopes, whereas others like forward-viewing reflectance or fluorescence imaging, may require performance tradeoffs. The development of small, robust and fiber-delivered advanced light sources, miniature fiber bundles, and sensitive detectors has aided the development of novel miniature endoscopes. In this talk, I will discuss our recent advancements in endoscope design for multimodality optical early detection of ovarian cancer.

Vision guides thought and action. To do so usefully it must inform us about critical features of the world around us. What we can learn about the world is limited by the initial stages of visual processing. Physicists, biologists and psychologists have created quantitative models of these stages, and these models enable us to quantify the encoded information. We have integrated these models as image computable software: the Image Systems Engineering Toolbox for Biology (ISETBio). The software is an extensible set of open-source modules that model the three-dimensional scene spectral radiance, retinal image formation (physiological optics), spatial sampling by the cone photoreceptor mosaic, fixational eye movements, and phototransduction. This webinar, hosted by the OSA Color Technical Group, will provide an overview of the ISETBio modules as well as examples of how to use the software to understand and model human visual performance.

Hosted By: Color Technical Group

This talk describes ThinVR: An approach to build near-eye VR displays that simultaneously provides a very wide (180 degree horizontal) FOV and a compact form factor. The key is to replace traditional large optics with curved microlens arrays and to place the optics in front of curved displays. We had to design custom heterogeneous optics to make this approach work, because many lenslets are viewed off the central axis. To ensure the existence of an adequate eyebox and to minimize pupil swim distortions, we had to design and build a custom optimizer to produce an acceptable heterogeneous lenslet array. We prove this approach works through prototypes with both static and dynamic displays. To our knowledge, this is the first work to both convincingly demonstrate and analyze the potential for curved, heterogeneous microlens arrays to enable compact, wide FOV near-eye VR displays.

Although treatment algorithms vary, surgery is the primary treatment modality for most solid cancers. In oncologic tumor resection, the preferred outcome is complete cancer removal as residual tumor left behind is considered treatment failure. However complete tumor removal needs to be balanced with functional preservation and minimizing patient morbidity including prevention of inadvertent nerve injury. The inability of surgeons to visually distinguish between tumor and normal tissue including nerves leads to residual cancer cells being left behind at the edges of resection, i.e. positive surgical margins (PSM). PSM can be as high as 20-40% in breast cancer lumpectomy, 21% for radical prostatectomy, and 13% for HNSCC. Similarly, using white light reflectance alone which is the current standard of care in operating rooms, nerve dysfunction following surgery has been reported to be as high as ~2-40% ranging from immediate post op to long-term dysfunction.

Molecular imaging with fluorescence provides enhanced visual definition between diseased and normal tissue and have been shown to decrease PSM in both animal models and patients. Molecular imaging with fluorescence can also provide enhanced visualization of important structures such as nerves to improve preservation and minimize inadvertent injury. Our laboratory has extensive experience in development of both nerve and tumor injectable markers for surgical visualization. In presentation we will discuss the development of nerve and tumor markers combinations to improve intraoperative visualization – aka Precision Surgery TM.

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Lidar systems are used in diverse applications, including autonomous driving and industrial automation. Despite the challenging requirements for these systems, most lidars in the market utilize legacy technologies such as scanning mechanisms, long-coherence-length or edge-emitting lasers, and avalanche photodiodes, and consequently offer limited performance and robustness at a relatively high price point. Other systems propose to utilize esoteric technologies which face an uphill struggle towards manufacturability. This talk will describe two complementary technologies, leveraging on years of progress in adjacent industries. When combined with novel signal processing algorithms, these deliver a high-resolution, long-range and low-cost solid-state flash lidar system, breaking the performance envelope and resulting in a camera-like system. We will discuss design trade-offs, performance roadmap into the future and remaining challenges.

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Compressive imaging enables faster acquisitions by capturing coded projections of the scenes. Codification elements used in compressive imaging systems include lithographic masks, gratings and micro-polarizers, which sense spatial, spectral, and temporal data. Codification plays a key role in compressive imaging as it determines the number of projections needed for correct reconstruction. In general, random coding patterns are sufficient for accurate reconstruction. Still, more recent studies have shown that code design not only yields to improved image reconstructions, but it can also reduce the number of required projections. This talk covers different tools for codification design in compressive imaging, such as the restricted isometry property, geometric and deep learning approaches. Applications in compressive spectral video, compressive X-ray computed tomography, and seismic acquisition will be also discussed.

After working in stealth for over 4 years, Mojo Vision recently unveiled the first working prototype of Mojo Lens, a smart contact lens designed to deliver augmented reality content wherever you look. This talk will provide an overview of the company, its vision of "Invisible Computing", the science behind the world's first contact lens display, and a first-hand account of what it's like to actually wear Mojo Lens.