Diffuse optical spectroscopy and imaging (DOSI) is a class of non-invasive near-infrared imaging techniques based upon measuring the wavelength-dependent absorption and (reduced) scattering optical properties of living tissues. In the far-red to near-infrared optical therapeutic window, these optical properties provide information about deep (several cm) tissue composition, structure, and oxygen metabolism. In particular, DOSI is capable of quantifying tissue concentrations of the physiologically relevant molecules oxyhemoglobin, deoxygenated hemoglobin, lipid, and water, as well as structural parameters including cellular size and density (obtained from scattering spectra). The significance and applicability of these and other DOSI biomarkers collected with research devices have been demonstrated in numerous clinical studies of oncology, cardiovascular assessment, exercise physiology, and neuroscience.
In this presentation, I will discuss how DOSI has shown promise in the field of breast oncology for risk assessment, screening, differential diagnosis of benign and malignant lesions, and predicting and monitoring response to chemotherapy treatment. DOSI biomarkers vary significantly in abundance and molecular state between breast cancer and normal tissue and unique cancer-specific absorption signatures have been observed. Finally, I will demonstrate how we are working to translate this promising technology to clinical practice and my vision for the future.