Applied Physics / Physics Colloquium

Physical Sciences Approaches to Analyze Tumor-Associated ECM Dynamics

Topic: 
Physical Sciences Approaches to Analyze Tumor-Associated ECM Dynamics
Abstract / Description: 

Stanford Center for Cancer Systems Biology (CCSB) presents:

Claudia Fischbach-Teschl, PhD
Professor, Nancy E. and Peter C. Meinig School of Biomedical Engineering
Director, Cornell Center on the Physics of Cancer Metabolism Cornell University

"Physical Sciences Approaches to Analyze Tumor-Associated ECM Dynamics"

ABSTRACT:
Microenvironmental conditions contribute to the pathogenesis of cancer and include altered cellular composition, extracellular matrix (ECM) deposition, and mechanical cues. However, our understanding of the specific mechanisms by which these microenvironmental perturbations impact the development, progression, and therapy response of cancer is relatively limited. More intricate models are needed to better understand the complex biochemical and biophysical interactions that drive tumor initiation, growth, metastasis, metabolic adaptation, and immune evasion. The fields of biomaterials and tissue engineering provide increasingly sophisticated tools and strategies to recapitulate and monitor relevant properties of tumor-microenvironment interactions.


These approaches not only bear tremendous potential to advance our current understanding of cancer, but are also increasingly explored for more clinically relevant drug testing. Indeed, combining patient-specific cells with engineered culture systems promises to enhance the predictive power of precision medicine pipelines. This talk will highlight specific examples of how the microenvironment regulates the highly dynamic nature of cancer and will outline opportunities and challenges of the field of tumor engineering.

Date and Time: 
Thursday, May 23, 2019 - 2:30pm
Venue: 
Clark Center - S360

KIPAC welcomes Professor Jo Dunkley

Topic: 
Our Universe
Abstract / Description: 

Most of us have heard of black holes and supernovas, galaxies and the Big Bang. But few of us understand more than the bare facts about the universe we call home. What is really out there? How did it all begin? Where are we going? Jo Dunkley begins in Earth's neighborhood, explaining the nature of the Solar System, the stars in our night sky, and the Milky Way. She then moves out past nearby galaxies and back in time to the horizon of the observable universe, which contains over a hundred billion galaxies, each with billions of stars, many orbited by planets, some of which may host life. Dunkley traces the evolution of the universe from the Big Bang fourteen billion years ago, past the birth of the Sun and our planets, to today and beyond.

Date and Time: 
Thursday, May 9, 2019 - 7:00pm
Venue: 
Hewlett Building

#StanfordToo: A Conversation about Sexual Harassment in Our Academic Spaces

Topic: 
#StanfordToo: A Conversation about Sexual Harassment in Our Academic Spaces
Abstract / Description: 

Individuals of all genders invited to be a part of:
#StanfordToo: A Conversation about Sexual Harassment in Our Academic Spaces, where we will feature real stories of harassment at Stanford academic STEM in a conversation with Provost Drell, Dean Minor (SoM), and Dean Graham (SE3). We will have plenty of time for audience discussion on how we can take concrete action to dismantle this culture and actively work towards a more inclusive Stanford for everyone. While our emphasis is on STEM fields, we welcome and encourage participation from students, postdocs, staff, and faculty of all academic disciplines and backgrounds.

Date and Time: 
Friday, April 19, 2019 - 3:30pm
Venue: 
STLC 111

Applied Physics/Physics Colloquium presents "Testing DAMA's long-standing claim for dark matter detection"

Topic: 
Testing DAMA's long-standing claim for dark matter detection
Abstract / Description: 

Astrophysical observations give overwhelming evidence for the existence of dark matter. Several theoretical particles have been proposed as dark matter candidates, including weakly interacting massive particles (WIMPs), axions, and more recently, their much lighter counterparts. However there has not yet been a definitive detection of dark matter. One group, the DAMA collaboration, has asserted for years that they observe a dark matter-induced annual modulation signal in their NaI(Tl)-based detectors. Their observations seem to be inconsistent with those from other direct detection dark matter experiments under most assumptions of dark matter. In this talk I will describe the current status of the debate and the world-wide experimental effort to test this extraordinary claim. I will report the recent results from the COSINE-100 experiment and our progress toward resolving the current stalemate in the field.

 

Date and Time: 
Tuesday, June 4, 2019 - 4:30pm
Venue: 
Hewlett 201

Applied Physics/Physics Colloquium presents The Dawn of Superconducting Quantum Processors"

Topic: 
The Dawn of Superconducting Quantum Processors
Abstract / Description: 

Quantum coherence can now be observed for longer than 100 microseconds in superconducting chips containing tens of physical qubits comprised of Josephson tunnel junctions embedded in resonant microwave circuitry. Combining such long-lived coherence with quantum-noise-limited, broadband detection of weak microwave signals has enabled the realization of nascent quantum processors suitable for executing shallow-circuit quantum algorithms with modest gate counts and minimal error mitigation. As an example, I will describe the implementation of a hybrid quantum-classical variational eigensolver with superconducting transmon qubits to determine the ground and excited states of simple molecules with near-chemical accuracy, and a teleportation protocol using ternary logic to simulate scrambling processes in black holes.

Date and Time: 
Tuesday, May 28, 2019 - 4:30pm
Venue: 
Hewlett 201

Applied Physics/Physics Colloquium presents "Strongly Interacting Synthetic Topological Insulators in High Dimensions"

Topic: 
Strongly Interacting Synthetic Topological Insulators in High Dimensions
Abstract / Description: 

Although our physical world is 3+1 dimensional, curiosity has always driven scientists to study higher dimensional physics. The classic examples of such studies include the 4+1 dimensional generalization of quantum Hall state, and the "periodic table" of topological insulators in all dimensions. These studies are of pure theoretical interests only until last year, when a 4+1 dimensional topological insulator was realized in cold atom systems using the "synthetic techniques". The same technique allows us to explore even higher dimensional states of matter experimentally. In this talk we will discuss the interaction effects in these "synthetic topological insulators" in high dimensions. We realize that the generic interaction in this system takes a special form which is very different from ordinary condensed matter systems, and it has strong implications on the classification and phenomena of these synthetic topological insulators.

 

Date and Time: 
Tuesday, May 21, 2019 - 4:30pm
Venue: 
Hewlett 201

Applied Physics/Physics Colloquium presents "Physicists and Evolution: Puzzles and Expectations"

Topic: 
Physicists and Evolution: Puzzles and Expectations
Abstract / Description: 

To most physicists, almost everything about evolution is puzzling. What determines how much complexity can — and has — evolved? Why is there so much biological diversity on all scales of differences? How could evolution select for future "evolvability"? Why doesn't evolution get slower and slower? One of the roles of theory is to frame questions — or at least limited versions of them — more precisely. And another is to reduce — or redirect — puzzlement by developing and analyzing simple caricature models to see what should be expected rather than be surprising. This talk will outline some recent progress in these directions, particularly by statistical physics ways of thinking.

Date and Time: 
Tuesday, May 14, 2019 - 4:30pm
Venue: 
Hewlett 201

Applied Physics/Physics Colloquium presents "From Nonlinear Optics to High-Intensity Laser Physics"

Topic: 
From Nonlinear Optics to High-Intensity Laser Physics
Abstract / Description: 

The laser increased the intensity of light that can be generated by orders of magnitude and thus brought about nonlinear optical interactions with matter. Chirped pulse amplification, also known as CPA, changed the intensity level by a few more orders of magnitude and helped usher in a new type of laser-matter interaction that is referred to as high-intensity laser physics. In this talk, I will discuss the differences between nonlinear optics and high-intensity laser physics. The development of CPA and why short, intense laser pulses can cut transparent material will also be included. I will also discuss future applications.

Date and Time: 
Tuesday, May 7, 2019 - 11:20am
Venue: 
Hewlett 201

Applied Physics/Physics Colloquium presents Imaging at the genomic-scale: from 3D organization of the genome to cell atlas of the brain

Topic: 
Imaging at the genomic-scale: from 3D organization of the genome to cell atlas of the brain
Abstract / Description: 

Inside a cell, thousands of different genes function collectively to give rise to cellular behavior. Understanding the emergent behaviors of cells requires imaging at the genomic scale, which promises to transform our understanding in many areas of biology, such as regulation of gene expression, development of cell fate, and organization of distinct cell types in complex tissues. We developed a genomic-scale imaging method, MERFISH, which allows simultaneous imaging of hundreds to thousands of genes in individual cells and facilitates the delineation of gene regulatory networks, the mapping of molecular distribution inside cells, and the mapping of distinct cell types in complex tissues. We have also extended this approach to image numerous genomic loci and trace the 3D structure of chromosomes in single cells. I will describe the technology development of MERFISH and its applications, focusing on generating the cell atlas of complex tissues and mapping the 3D organization of the genome. 

Date and Time: 
Tuesday, April 30, 2019 - 4:30pm
Venue: 
Hewlett 201

Applied Physics/Physics Colloquium presents Matter made of Light: Mott Insulators and Topological Fields

Topic: 
Matter made of Light: Mott Insulators and Topological Fields
Abstract / Description: 

In this talk I will describe our ongoing effort at the University of Chicago to explore exotic models of condensed matter using materials made of light. Starting with a quick discussion of "light as matter," I will then explain how we imbue photons with the essential attributes of a material particle: mass, charge, and interactions. Along the way, I will introduce the two "flavors" of photons that we employ for our photonic matter: optical photons trapped in Fabry-Perot cavities, and microwave photons trapped in superconducting resonators or transmon qubits. Finally, I will describe the first two materials that have emerged from our interacting photons: a Mott insulator of microwave photons and a topological fluid of optical photons. More broadly, building materials from light impacts both (a) the kinds of matter that can be assembled, and (b) the assembly process itself, providing a new window on the physics of correlated quantum matter.

Date and Time: 
Tuesday, April 23, 2019 - 4:30pm
Venue: 
Hewlett 201

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