Metabolism during pregnancy is a dynamic and precisely programmed process, the failure of which can bring devastating consequences to the mother and fetus. To define a high-resolution temporal profile of metabolites during healthy pregnancy and the postpartum period, we carried out an untargeted metabolome investigation of 784 blood samples collected weekly from 30 healthy pregnant Danish women. The study revealed broad metabolome changes during normal pregnancy: of 9,651 detected metabolic features, 4,995 were significantly changed (FDR < 0.05). Of these, 460 annotated compounds (of 687 total) and 34 human metabolic pathways (of 48 total) were significantly altered during pregnancy, revealing a highly choreographed metabolic profile. Using linear models, we built a metabolic clock with metabolites that times gestational age in high accordance with first-trimester ultrasound. Our study represents the first weekly characterization of the human pregnancy metabolome, providing a high-resolution view for understanding human pregnancy with a potential clinical utility.The Workshop is held from 1:30-2:50pm in Medical School Office Building (MSOB), Rm x303, 1265 Welch Road, Stanford, unless otherwise specified on the calendar at the link below.
