Label-free optical imaging of living biological systems offers rich information that can be of immense value for a variety of biomedical tasks. Despite the exceptional theoretical potential, current label-free microscopy platforms are challenging for real-world clinical and biological applications. The major obstacles include the lack of flexible laser sources, limited contrast, and the challenge of acquiring and interpreting the high-dimensional dataset.
In this talk, I will present new optical imaging platforms and methodologies that will address these challenges. By generating and tailoring coherent supercontinuum from photonic crystal fibers, simultaneous metabolic and structural imaging can be achieved without aids of stains, enabling perturbation-free exploration of living systems. These capabilities further motivate development of analytical tools for image-based segmentation and diagnosis, showing broad potential of this label-free imaging technology in discovering new metabolic biomarkers and enabling real-time point-of-procedure applications.
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Sixian You is a postdoctoral research fellow in the Computational Imaging Lab at UC Berkeley and will join MIT EECS department in March 2021. Previously, Sixian received her Ph.D. in 2019 from the University of Illnois, Urbana-Champaign (UIUC) where she studied biomedical optical imaging with Dr. Stephen Boppart and Dr. Saurabh Sinha. Between Ph.D. and postdoc, she worked on optical sensing technologies at Apple. Her primary research interest is in developing innovative optical imaging solutions for biomedicine.