Advanced optical microscopy techniques have enabled the recording and stimulation of large populations of neurons deep within living, intact animal brains. I will present a broad overview of these techniques, and discuss challenges that still remain in performing large-scale imaging with high spatio-temporal resolution, along with various strategies that are being adopted to address these challenges.
Jerome Mertz received an AB in physics from Princeton University in 1984, and a PhD in quantum optics from UC Santa Barbara and the University of Paris VI in 1991. Following postdoctoral studies at the University of Konstanz and at Cornell University, he became a CNRS research director at the Ecole Supérieure de Physique et de Chimie Industrielle in Paris. He is currently a professor of Biomedical Engineering at Boston University. His interests are in the development and applications of novel optical microscopy techniques for biological imaging. He is also author of a textbook titled "Introduction to Optical Microscopy".