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Electronics Meets Pharmaceuticals: Getting the Most out of Every Pill

Electronics Meets Pharmaceuticals: Getting the Most out of Every Pill
Monday, March 2, 2015 - 4:00pm to 5:00pm
AllenX Auditorium
Mark Zdeblick, Ph.D. (CTO, Proteus Digital Health)
Abstract / Description: 

The practice of medicine didn't evolve for thousands of years. Starting about 100 years ago during the great influenza pandemic, the optical microscope ushered in a century of technological innovation in medicine that continues to cure disease and improve and extend the lives of millions of people. Better microscopes, such as CAT, MRI & PET scanners, enabled accurate diagnosis; pharmaceuticals tested using the scientific method gave doctors therapies to treat formerly incurable disease. Today, the study of genomics continues to revolutionize biochemistry, while mobile technology will bring these miracles to everyone, everywhere.

This presentation will first review a framework of innovation within the intersection of healthcare and mobile technology. Examples will show how mobile devices are reducing the cost and improving the performance of healthcare in the developed world while bringing modern miracles to underdeveloped regions. Proteus Digital Health® has combined electronics and pharmaceuticals to create digital medicines and wearable physiologic sensors.

The Proteus method can provide insights into medication taking behaviors and a patient's physiological response that will enable clinicians to make more informed therapeutic decisions and have evidence-based discussions with their patients on how best to approach management of their condition. By providing information to differentiate between non-response and nonadherence, the Proteus technique optimizes therapy costs (i.e. avoid unnecessary therapy changes and escalation to higher cost drugs) and use of medical resources (i.e. prevent unnecessary specialist referrals and costly complications), facilitating efficient progression through the recommended treatment pathway, and advancing patients towards their treatment goals. In the developing world, digital medicines will target the scourge of counterfeit medicines, which contaminate roughly half of Africa's supply chain.

The Proteus Patch, Ingestible Sensor, and related software will be presented. The Proteus Patch is a wearable data-logger for ambulatory recording of physiological metrics such as heart rate, activity, body angle relative to gravity, and time-stamped events, including events signaled by swallowing the Ingestible Sensor. Data from eleven clinical studies involving 492 subjects and ingestion of 20,993 ingestible sensors will be summarized.

Prior to co-founding Proteus Digital Health, Mark Zdeblick served as the chief technology officer for the optical switch group at K2 Optronics. Dr. Zdeblick is also founder, director and past chief technical officer of Redwood Microsystems, early developer of microfabricated valves and electro-fluidic integrated circuits. While working in Professor Calvin Quate's group at Stanford, Dr. Zdeblick co-invented the microfabricated cantilever beam with an atomically sharp tip that enabled atomic force microscopy. He holds a B.S. in civil engineering and a B.F.A.A. in architecture, both from the University of Illinois, and an M.S. in aeronautics and astronautics and Ph.D. in electrical engineering from Stanford University.