A biosensor capable of continuously measuring specific molecules in vivo would provide a valuable window into patients' health status and their response to therapeutics. Unfortunately, continuous, real-time molecular measurement is currently limited to a handful of analytes (i.e. glucose and oxygen) and these sensors cannot be generalized to measure other analytes. In this talk, we will present a biosensor technology that can be generalized to measure a wide range of biomolecules in living subjects. To achieve this, we develop synthetic antibodies (aptamers) that change its structure upon binding to its target analyte and produce an electrochemical current or emit light. Our real-time biosensor requires no exogenous reagents and can be readily reconfigured to measure different target analytes by exchanging the aptamer probes in a modular manner. Using our real-time biosensor, we demonstrate the first closed loop feedback control of drug concentration in live animals and discuss potential applications of this technology. Finally, we will discuss methods for generating the aptamer probes which are at the heart of this biosensor technology.
This seminar is sponsored by the Department of Applied Physics and the Ginzton Laboratory
Bio: Dr. H. Tom Soh is a Professor of Electrical Engineering and Radiology at Stanford University. His laboratory develops synthetic biomaterials and biosensor devices. He earned his B.S, with a double major in Mechanical Engineering and Materials Science with Distinction from Cornell University and Ph.D. in Electrical Engineering from Stanford University. Between 1999 and 2003, he served as a technical manager of MEMS device research group at Bell Laboratories and Agere Systems. Between 2003 and 2015, he was the Ruth Garland Professor at UC-Santa Barbara (UCSB) in the department of Mechanical Engineering and Materials. His lab moved to Stanford in 2015. He is a recipient of numerous awards including MIT Technology Review's "TR 100" Award, ONR Young Investigator Award, Beckman Young Investigator Award, ALA Innovator Award, NIH Director's TR01 Award, NIH Edward Nagy Award, Guggenheim Fellowship, and Alexander van Humboldt Fellowship. Dr. Soh is a Chan-Zuckerberg Biohub Investigator, fellow of the American Institute for Medical and Biological Engineering (AIMBE), and member of the National Academy of Inventors (NAI).