The majority of the cells in the retina do not reproduce, making early diagnosing of eye disease paramount. Through improved resolution provided by the correction of the ocular monochromatic aberrations, adaptive optics combined with conventional and novel imaging techniques reveal pathology at the cellular-scale. When compared with existing clinical tools, the ability to visualize retinal cells and microscopic structures non-invasively represents a quantum leap in the potential for diagnosing and managing ocular, systemic and neurological diseases. The presentation will first cover the adaptive optics technology itself and some of its unique technical challenges. This will be followed by a review of AO-enhanced imaging modalities applied to the study of the healthy and diseased eye, with particular focus on multiple-scattering imaging to reveal transparent retinal structures.
Alfredo (Alf) Dubra is an Associate Professor of Ophthalmology at Stanford (Byers Eye Institute). He trained in Physics in the Universidad de la República in Uruguay (BSc and MSc) and at Imperial College London in the United Kingdom (PhD). Before joining Stanford, he was with the University of Rochester and the Medical College of Wisconsin. His research focuses on the translation of mathematical, engineering and optical tools for the diagnosing, monitoring progression and treatment of ocular disease.