Using a large area transducer, ultrasound can be focused into the body without any damage to intervening tissue. In ablative applications in the brain, such as treatment of essential tremor or Parkinsonian tremor, MRI is used for targeting and for monitoring tissue temperature. Another important application of focused ultrasound is opening the blood-brain barrier for the delivery of therapeutics, such as chemotherapy and antibodies. In ultrasound-based neuromodulation, the brain is directly stimulated. For all these applications, Dr. Pauly will describe her?lab's?work to calibrate the beam pressure with patient-specific trans-skull simulation and MR acoustic radiation force imaging. Additionally, she will describe her work in phase aberration correction using MR acoustic radiation force imaging and beam simulations.
Kim Butts Pauly obtained a B.S. in Physics from Duke University. She received a Ph.D. from the Mayo Graduate School where she studied diagnostic MRI physics. After a postdoc at Stanford, she joined the faculty in the Department of Radiology at Stanford in 1996. Her work is currently focused on MRI-guided focused ultrasound in applications ranging from cancer treatment to functional disorders. She currently has courtesy appointments in both Biomedical Engineering and Electrical Engineering and is co-division chief for the Radiological Sciences Laboratory within Radiology.